A pig's brain has been frozen with its cellular activity locked in place

Recorded: March 21, 2026, 10 p.m.

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Major leap towards reanimation after death as mammal's brain preserved | New Scientist

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Major leap towards reanimation after death as mammal's brain preserved
A pig's brain has been frozen with its cellular activity locked in place and minimal damage. Some believe the same could be done with the brains of people with a terminal illness, so their mind can be reconstructed and they can "continue with their life"
By Helen Thomson

20 March 2026

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Could our brains one day be preserved in a way that locks in our thoughts, feelings and perceptions?SAMUNELLA/SCIENCE PHOTO LIBRARY
An entire mammalian brain has been successfully preserved using a technique that will now be offered to people who are terminally ill. The intention is to preserve all the neural information thought necessary to one day reconstruct the mind of the person it once belonged to.
“They would need to donate their brain and body for scientific research,” says Borys Wróbel at Nectome in San Francisco, California, a research company focused on memory preservation. “But what we are offering, as a company, is for their body and brain to be kept, essentially indefinitely, in the hope that sometime, in the future, it would be possible to read out the information from the brain and reconstruct the person… to allow them to continue, in effect, with their life.”
Read moreFrozen human brain tissue can now be revived without damage
When it comes to preserving the minute architecture of the brain, timing is critical. Within minutes of blood no longer circulating, enzymes break down neurons and cells start digesting themselves.
Cryonics usually involves preserving people’s bodies at sub-zero temperatures in the hope that they could one day be revived if a treatment or cure for their medical condition becomes available. Traditionally, this aims to preserve the brain quickly after natural death by cooling it and adding fixatives, but unless the cryonics team is at a person’s bedside, deterioration will have already begun before this occurs.
To circumvent this problem, Wróbel and his team have developed a protocol that is compatible with physician-assisted death, in which a person who is terminally ill chooses the time of their passing. The idea is that by intervening immediately, scientists may have the best chance of preserving the brain in a state that closely reflects a living condition.

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Wróbel’s team tested the protocol on pigs, which have brain and cardiovascular anatomy that is comparable to people. First, they inserted a cannula into the heart roughly 1 minute after cardiac arrest, before flushing out the blood and introducing preservation solutions into the brain. These fluids contain aldehyde chemicals, which create molecular bridges between cells, essentially locking cellular activity in place.
They then introduce cryoprotectants, which replace water within tissue, preventing the formation of ice crystals during cooling, which would otherwise damage cells. Next, the brain was cooled to around -32° C, at which temperature cryoprotectants form a glass-like state. The structure of the brain can then be preserved indefinitely.
To assess how well this worked, the team took samples from the brain’s outermost layer and examined them using microscopy. Early attempts, in which perfusion began around 18 minutes after death, showed clear signs of cellular damage. After reducing this delay to just under 14 minutes, the tissue showed excellent preservation of the minute structures, including neurons, synapses and the molecules that compose them.
Wróbel says that in theory, they could use this protocol “to reconstruct the three-dimensional structure of the neurons and the connections between them”. This is known as the connectome, and it is hoped that, by mapping it out, it might help us understand how the brain produces our thoughts, feelings and perceptions. So far, scientists have managed to map only a small part of the mouse brain in this way, which took seven years to complete.
Could brain freezing cure all disease – indirectly?Neuroscientist Ariel Zeleznikow-Johnston's book The Future Loves You presents a bold new take on dying
Despite advances in both cryopreservation and computing, “reanimation” isn’t yet an option. “The approach is essentially a form of fixation using toxic chemicals that preserves the structure of the brain and neurons, but without expectation of biological viability,” says Joao Pedro de Magalhaes at the University of Birmingham, UK. “There is currently no way to revive an organ preserved in this way, as it is a sort of embalming.”
De Magalhaes also isn’t convinced that a person could “live on” by reconstructing their connectome. “Even a perfect copy of my mind would still be a different entity, although I appreciate that some people see this as a potential path to a sort of ‘virtual immortality,’” he says.
Nevertheless, Wróbel’s team thinks the human mind could one day be recreated, digitally or biologically. “Although we’re agnostic towards the type of revival methods, we think we may be able to preserve all the information needed for revival,” says Wróbel.
Don't disrespect Alan Turing by reanimating him with AIPlans to create an interactive AI model of the legendary code breaker Alan Turing are reckless and problematic, says Matthew Sparkes
He says the team at Nectome is preparing to invite people with a terminal illness to Oregon, where they can spend a few days with their family, before taking part in the new protocol. “They would come to us, take the medication – which would have to be prescribed by an independent doctor, not us – and then, after it is legal to do so, we would start the surgery,” says Wróbel.
Regardless of hypothetical futures, the work raises profound philosophical questions about our definition of death. “It’s long been known that declaration of death based on stopped blood circulation is a formalised prognosis of futility, not a metaphysical event,” says Brian Wowk at biotechnology company 21st Century Medicine in Fontana, California.
“The ability to preserve the detailed structural and molecular composition of a brain, perhaps even preserve what makes a person who they are at the most fundamental level – even after considerable periods of stopped blood circulation, as this study does – underscores that the difference between life and death is more complicated than just cessation of vital functions,” he says.
Reference:bioRxiv DOI: 10.64898/2026.03.04.709724
Topics:death/brain

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The research presented by Borys Wróbel and his team at Nectome represents a significant advancement in the potential for preserving mammalian brains, specifically aiming at the prospect of reconstructing a person’s mind after death. This endeavor hinges on a novel protocol utilizing immediate intervention following cardiac arrest – approximately 14 minutes after cessation of blood flow – to minimize the degenerative processes typically associated with brain preservation. The core of the technique involves injecting aldehyde chemicals to stabilize neuronal structures and cryoprotectants to mitigate ice crystal formation during cooling to -32°C, effectively creating a glass-like state that halts cellular activity and preserves the brain's intricate architecture.

The team successfully tested this protocol on pigs, demonstrating a remarkable reduction in cellular damage compared to previous attempts extending up to 18 minutes post-mortem. This achievement focuses on the critical timeframe immediately following death, a period previously considered too brief for effective preservation. The method’s success is tied to the ability to meticulously preserve the brain’s “connectome,” the three-dimensional mapping of neuronal connections, a feat previously considered largely unattainable. Wróbel envisions a future where this detailed map could be used to understand the basis of consciousness, thought, and perception. The research acknowledges the substantial challenge – a seven-year undertaking previously required to map a small portion of a mouse brain – but highlights the potential for dramatically reduced timelines with the new protocol.

However, the team stresses that the current technique is primarily focused on structural fixation, not biological revival. Joao Pedro de Magalhaes at the University of Birmingham cautions that even a perfect recreation of the connectome wouldn’t necessarily equate to a conscious entity, acknowledging the philosophical complexities inherent in the concept. Similarly, Ariel Zeleznikow-Johnston, in her book "The Future Loves You," highlights that the approach is akin to a highly detailed embalming process, devoid of inherent biological viability.

Despite the acknowledged limitations, Wróbel maintains the possibility of future revival, believing that the team can preserve all the information necessary, though the method of revival remains open to speculation. The protocol is currently geared toward offering a service to individuals facing terminal illnesses, allowing them to donate their bodies and brains for research with the hope of reconstruction. This involves a carefully orchestrated process, including a physician-prescribed medication administration.

Brian Wowk at 21st Century Medicine emphasizes that the concept shifts our understanding of death, positing that the distinction between life and death is more nuanced than simply the cessation of vital functions. This protocol underscores the intricate composition of the brain and its potential for preservation following significant periods without blood circulation.

The research raises pertinent philosophical questions regarding the definition of death, as highlighted by Wowk. The study’s success in preserving the molecular and structural details of the brain suggests a more complex relationship between life and death than previously assumed. While the technology is not currently capable of resuscitation, it represents a crucial step toward understanding the very nature of consciousness and, potentially, its preservation beyond biological death.