Didgeridoo playing as alternative treatment for obstructive sleep apnea(2006)

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Didgeridoo playing as alternative treatment for obstructive sleep apnoea syndrome: randomised controlled trial - PMC

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BMJ. 2006 Feb 4;332(7536):266–270. doi: 10.1136/bmj.38705.470590.55

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Didgeridoo playing as alternative treatment for obstructive sleep apnoea syndrome: randomised controlled trial
Milo A Puhan
Milo A Puhan

1 Horten Centre, University of Zurich, 8091 Zurich, Switzerland
research fellow
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1, Alex Suarez
Alex Suarez

2 Asate Alex Suarez, 9630 Wattwil, Switzerland
didgeridoo instructor
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2, Christian Lo Cascio
Christian Lo Cascio

3 Zuercher Hoehenklinik Wald, CH-8639 Faltigberg-Wald, Switzerland
resident in internal medicine
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3, Alfred Zahn
Alfred Zahn

3 Zuercher Hoehenklinik Wald, CH-8639 Faltigberg-Wald, Switzerland
sleep laboratory technician
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3, Markus Heitz
Markus Heitz

4 Lungenpraxis Morgental, Zurich, Switzerland
specialist in respiratory and sleep medicine
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4, Otto Braendli
Otto Braendli

3 Zuercher Hoehenklinik Wald, CH-8639 Faltigberg-Wald, Switzerland
specialist in respiratory and sleep medicine
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Author information
Article notes
Copyright and License information

1 Horten Centre, University of Zurich, 8091 Zurich, Switzerland

2 Asate Alex Suarez, 9630 Wattwil, Switzerland

3 Zuercher Hoehenklinik Wald, CH-8639 Faltigberg-Wald, Switzerland

4 Lungenpraxis Morgental, Zurich, Switzerland
Correspondence to: O Braendli otto.braendli@zhw.ch
Roles

Milo A Puhan: research fellow

Alex Suarez: didgeridoo instructor

Christian Lo Cascio: resident in internal medicine

Alfred Zahn: sleep laboratory technician

Markus Heitz: specialist in respiratory and sleep medicine

Otto Braendli: specialist in respiratory and sleep medicine

Accepted 2005 Nov 24.

PMCID: PMC1360393 PMID: 16377643

Abstract
Objective To assess the effects of didgeridoo playing on daytime sleepiness and other outcomes related to sleep by reducing collapsibility of the upper airways in patients with moderate obstructive sleep apnoea syndrome and snoring.
Design Randomised controlled trial.
Setting Private practice of a didgeridoo instructor and a single centre for sleep medicine.
Participants 25 patients aged > 18 years with an apnoea-hypopnoea index between 15 and 30 and who complained about snoring.
Interventions Didgeridoo lessons and daily practice at home with standardised instruments for four months. Participants in the control group remained on the waiting list for lessons.
Main outcome measure Daytime sleepiness (Epworth scale from 0 (no daytime sleepiness) to 24), sleep quality (Pittsburgh quality of sleep index from 0 (excellent sleep quality) to 21), partner rating of sleep disturbance (visual analogue scale from 0 (not disturbed) to 10), apnoea-hypopnoea index, and health related quality of life (SF-36).
Results Participants in the didgeridoo group practised an average of 5.9 days a week (SD 0.86) for 25.3 minutes (SD 3.4). Compared with the control group in the didgeridoo group daytime sleepiness (difference -3.0, 95% confidence interval -5.7 to -0.3, P = 0.03) and apnoea-hypopnoea index (difference -6.2, -12.3 to -0.1, P = 0.05) improved significantly and partners reported less sleep disturbance (difference -2.8, -4.7 to -0.9, P < 0.01). There was no effect on the quality of sleep (difference -0.7, -2.1 to 0.6, P = 0.27). The combined analysis of sleep related outcomes showed a moderate to large effect of didgeridoo playing (difference between summary z scores -0.78 SD units, -1.27 to -0.28, P < 0.01). Changes in health related quality of life did not differ between groups.
Conclusion Regular didgeridoo playing is an effective treatment alternative well accepted by patients with moderate obstructive sleep apnoea syndrome.
Trial registration ISRCTN: 31571714.Introduction
Snoring and obstructive sleep apnoea syndrome are two highly prevalent sleep disorders caused by collapse of the upper airways.1,2,3 The most effective intervention for these disorders is continuous positive airway pressure therapy, which reduces daytime sleepiness4 and the risk of cardiovascular morbidity and mortality in the most severely affected patients (apnoea-hypopnoea index (measured as episodes per hour) > 30).5 For moderately affected patients (apnoea-hypopnoea index 15-30) who complain about snoring and daytime sleepiness, however, continuous positive airway pressure therapy may not be suitable and other effective interventions are needed.1,6,7
AS, a didgeridoo instructor, reported that he and some of his students experienced reduced daytime sleepiness and snoring after practising with this instrument for several months. In one person, the apnoea-hypopnoea index decreased from 17 to 2. This might be due to training of the muscles of the upper airways, which control airway dilation and wall stiffening.8,9,10 We tested the hypothesis that training of the upper airways by didgeridoo playing reduces daytime sleepiness in moderately affected patients.Methods
Participants and methods
We included German speaking participants aged > 18 years with self reported snoring and an apnoea-hypopnoea index of 15-30 (determined by a specialist in sleep medicine within the past year). Exclusion criteria were current continuous positive airway pressure therapy, use of drugs that act on the central nervous system (such as benzodiazepines), current or planned intervention for weight reduction, consumption of ≥ 14 alcoholic drinks a week or ≥ 2 a day, and obesity (body mass index ≥ 30 kg/m2).
We recruited patients at our study centre (Zuercher Hoehenklinik Wald, Wald, Switzerland) and one private practice in Zurich. Physicians at the study centre assessed all potential participants for eligibility. Those willing to participate provided written informed consent. After study enrolment, all patients completed a baseline assessment.
We randomised enrolled patients into an intervention group with didgeridoo training or a control group. We used STATA software (STATA 8.2, College Station, Tx) to generate the randomisation list (ralloc command) with stratification for disease severity (apnoea-hypopnoea index 15-21 or 22-30 and Epworth score < 12 or ≥ 12). The randomisation list was concealed from the recruiting physicians and the didgeridoo instructor in an administrative office otherwise not involved in the study. We used a central telephone service, which the didgeridoo instructor used to obtain group allocation.Intervention and control
Participants in the intervention group started their didgeridoo training after the instructor received group allocation. The instructor (AS) gave the first individual lesson immediately after randomisation. In the first lesson, participants learnt the lip technique to produce and hold the keynote for 20-30 seconds. In the second lesson (week 2) the instructor explained the concept and technique of circular breathing. Circular breathing is a technique that enables the wind instrumentalist to maintain a sound for long periods of time by inhaling through the nose while maintaining airflow through the instrument, using the cheeks as bellows. In the third lesson (week 4) the didgeridoo instructor taught the participants his technique to further optimise the complex interaction between the lips, the vocal tract, and circular breathing so that the vibrations in the upper airway are more readily transmitted to the lower airways.11 In the fourth lesson, eight weeks after randomisation, the instructor and the participants repeated the basics of didgeridoo playing and made corrections when necessary. Participants had to practise at home for at least 20 minutes on at least five days a week and recorded the days with practice and the practice time (answer options for 0, 20, or 30 minutes).
Participants received a standardised acrylic plastic didgeridoo that was developed by the instructor in collaboration with Creacryl GmbH (Ebmatingen, Zurich, Switzerland, and costs €80 (£43; $94), fig 1). The didgeridoo is 130 cm long with a diameter of 4 cm and an elliptical embouchure with a diameter of 2.8-3.2 mm. Acrylic didgeridoos are easier for beginners to learn on than conventional wooden didgeridoos.
Fig 1.

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Man playing didgeridooParticipants in the control group remained on a waiting list to start their didgeridoo training after four months. They were not allowed to start didgeridoo playing during these four months.Outcome measures
Our primary outcome was daytime sleepiness as measured by the Epworth scale, which has been validated in German speaking patients.12 Scores range from 0 (no daytime sleepiness) to 24, and scores > 11 represent excessive daytime sleepiness.
Secondary outcomes included three additional sleep related outcomes measures: the apnoea-hypopnoea index, the Pittsburgh quality of sleep index, and a partner's rating for sleep disturbance.
The cardiorespiratory sleep study was performed at the sleep laboratory of the study centre with a computerised system (SleepLab Pro, Jaeger, Hoechberg, Germany), according to the guidelines of the German Society for Sleep Medicine.13 We measured airflow using nasal and oral thermistors and a nasal canula with a differential pressure flow sensor. We defined episodes of apnoea as cessation of airflow of > 10 seconds with decrements of blood oxygen saturation of ≥ 4%. Hypopnoea was defined as a reduced airflow for at least 10 seconds with decrements of blood oxygen saturation of ≥ 4% or waking, or both. The person who analysed the sleep recordings was blinded to group allocation throughout the trial.
The Pittsburgh quality of sleep index is a self administered questionnaire with 19 items to determine sleep quality, latency, duration, and disturbance within the past four weeks.14 The global score ranges from 0 to 21, with higher values representing worse quality of sleep. A score of ≥ 5 represents impaired sleep quality. We used a validated German version.15
The partners (when present) rated their sleep disturbance by the participants' snoring during the previous seven nights on a visual analogue scale from 0 to 10. The visual analogue scale was similar to a Borg scale and had verbal descriptors for 0 (not disturbed at all) to 5 (severely disturbed), 7 (very severely disturbed), 9 (very, very severely disturbed), and 10 (extremely disturbed). The partners completed the scale independently from the participants and sent it back to the study centre.
Finally, we used the German SF-36 to assess generic health related quality of life.16Analysis
We analysed all data on an intention to treat basis. For the primary analysis we compared change scores (differences between baseline and follow-up) between groups using two sample t tests. We also performed an analysis of covariance with the primary and secondary continuous end points at four months after randomisation as the dependent variables and their baseline values, markers of severity of disease (apnoea-hypopnoea index and Epworth score), weight change, and group allocation as independent variables.
We selected the Epworth scale as our primary outcome but also considered the three other sleep related outcomes (apnoea-hypopnoea index, Pittsburgh quality of sleep index, and partner rating). To provide an overall estimate of the effects of didgeridoo playing on the four outcome measures we used a summary measure described by Schouten.17 Briefly, for each patient and outcome we calculated a z score (difference of individual change minus overall mean change score/overall SD of change score) and then a summary score as the average of the four z scores. We compared these summary scores between the groups using a two sample t test.
For all analyses, we present 95% confidence intervals and considered P ≤ 0.05 as significant. All statistical analyses were performed with SPSS (12.0.1, Chicago, Ill).Results
Figure 2 shows the study flow from screening of potential participants to the final assessment. We included 25 patients from August 2004 to April 2005, all of whom completed the trial. Table 1 shows the participants' characteristics and the baseline values of the outcomes measures. Most patients were men, aged about 50, and had an average apnoea-hypopnoea index of 21 and excessive daytime sleepiness (mean Epworth scores 11.8 in the didgeridoo group and 11.1 in the control group). The Pittsburgh quality of sleep index indicated impaired sleep quality (5.2 and 5.8) and the partners of the study participants on average had severely disturbed sleep (5.6 and 5.5). The SF-36 scores were in the range of the normal population with exception of the mental component and vitality scores, which were lower (reference scores of 50 for mental component and 63.3 for vitality).
Fig 2.

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Flow of participants through studyTable 1.
Characteristics of participants according to allocation to intervention (didgeridoo) or control. Numbers are means (SD) except for absolute values

Didgeridoo group (n=14)
Control group (n=11)

Age (years)
49.9 (6.7)
47.0 (8.9)

Men
12
9

Years of snoring
8.7 (6.0)
8.9 (3.5)

Body mass index
25.8 (4.0)
25.9 (2.4)

Systolic blood pressure
133.7 (14.0)
133.3 (14.0)

Diastolic blood pressure
80.9 (7.1)
77.3 (8.4)

Used any medication
3
1

Played wind instrument
0
2

Drinks/week
2.2 (3.1)
2.2 (1.8)

Reason for study participation:

Snoring
14
10

Intolerance to CPAP therapy
0
1

Apnoea-hypopnoea index
22.3 (5.0)
19.9 (4.7)

Epworth scale
11.8 (3.5)
11.1 (6.4)

Pittsburgh quality of sleep index
5.2 (1.7)
5.8 (2.8)

Partner's rating of sleep disturbance
5.6 (2.4)*

5.5 (2.3)

SF-36:

Physical component score
52.7 (7.4)
52.7 (7.0)

Mental component score
41.1 (12.1)
44.8 (8.6)

Physical functioning
88.9 (11.3)
92.5 (8.9)

Role physical
76.2 (25.1)
82.5 (20.6)

Bodily pain
79.2 (22.0)
80.9 (29.1)

General health
70.4 (17.1)
69.9 (16.0)

Vitality
48.6 (15.2)
53.0 (11.1)

Social functioning
66.4 (20.6)
69.1 (14.7)

Role emotional
72.2 (27.9)
83.5 (17.4)

Mental health
66.9 (19.5)
68.4 (15.9)

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*One participant in the didgeridoo group did not have a partner.
On average, participants in the didgeridoo group practised on 5.9 days a week (SD 0.86, range 4.6-6.9) for 25.3 minutes (3.4). There were no adverse or unexpected events in either group. Table 2 shows the effects of didgeridoo playing on the four sleep related outcomes. The primary outcome (daytime sleepiness as measured by the Epworth scale) improved significantly in the didgeridoo group compared with the control group (difference -3.0 units, 95% confidence interval -5.7 to -0.3, P = 0.03). Figure 3 shows the individual responses in daytime sleepiness in the two groups.
Table 2.
Effects of intervention on sleep related outcomes

Outcome
Didgeridoo group
Control group

Raw difference*(95% CI)

Adjusted difference†(95% CI)

Epworth scale

At 4 months
7.4 (2.3)
9.6 (6.0)

Change from baseline
−4.4 (3.7)
−1.4 (2.6)
−3.0 (−5.7 to −0.3), P=0.03
−2.8 (−5.4 to −0.2), P=0.04

Pittsburgh quality of sleep index

At 4 months
4.3 (2.1)
5.6 (2.7)

Change from baseline
−0.9 (1.6)
−0.2 (1.7)
−0.7 (−2.1 to 0.6), P=0.27
−0.8 (−2.3 to 0.8), P=0.30

Partner rating of sleep disturbance

At 4 months
2.3 (1.4)
4.8 (2.2)

Change from baseline
−3.4 (2.4)
−0.6 (1.9)
−2.8 (−4.7 to −0.9), P<0.01
−2.7 (−4.2 to −1.2), P<0.01

Apnoea-hypopnoea index

At 4 months
11.6 (8.1)
15.4 (9.8)

Change from baseline
−10.7 (7.7)
−4.5 (6.9)
−6.2 (−12.3 to −0.1), P=0.05
−6.6 (−13.3 to −0.1), P=0.05

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*Two sample t tests.

†Analysis of covariance with adjustment for severity of disease (apnoea-hypopnoea index and Epworth scale) and weight change during study period.

Fig 3.

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Individual responses in daytime sleepiness, showing direction of changeThe quality of sleep did not differ significantly between groups (difference -0.7 units, -2.1 to 0.6, P = 0.27), but the partners of those in the didgeridoo group reported less sleep disturbance (difference -2.8 units, -4.7 to -0.9, P < 0.01). We also observed a significant effect of didgeridoo playing on apnoea-hypopnoea (difference for apnoea-hypopnoea index -6.2, -12.3 to -0.1, P = 0.05). Didgeridoo playing did not have a significant effect on any domain of the SF-36. Adjustment for severity of the condition and weight change during the study did not alter the results substantially for any outcome.
Figure 4 shows the combined analysis of the four sleep related outcomes. The summary z scores differed by -0.78 (-1.27 to -0.28, P < 0.01), favouring the didgeridoo over the control group.
Fig 4.

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Effects of didgeridoo playing on measure of sleep related outcomesDiscussion
In this randomised controlled trial we found that four months of training of the upper airways by didgeridoo playing reduces daytime sleepiness in people with snoring and obstructive sleep apnoea syndrome. The reduction of the apnoea-hypopnoea index by didgeridoo playing indicated that the collapsibility of the upper airways decreased. In addition, the partners of participants in the didgeridoo group were much less disturbed in their sleep.
Earlier studies about the effects of electrical neurostimulation or training of the respiratory muscles showed no improvement in daytime sleepiness11 or the apnoea-hypopnoea index18 or were limited by the lack of a control group.10 Our results are the first to show that training the upper airways significantly improves sleep related outcomes. The larger effects we observed may be due to the longer duration of our intervention and the training of the whole vocal tract instead of only single muscles.
Comparison with continuous positive airway pressure therapy
A meta-analysis of trials evaluating continuous positive airway pressure therapy in patients with moderate to severe obstructive sleep apnoea syndrome showed an average effect of -3.9 units on the Epworth scale.4 The minimum important difference on this scale for severely affected patients is around 4 units.19 In our trial, the mean change score in the didgeridoo group was -4.4 units and the difference between the intervention and control group was -3.0 units. Thus the effect of didgeridoo playing seems to be slightly smaller than with CPAP therapy. However, we expected smaller effects because our patients were only moderately affected so that results are likely to be less pronounced.
One of the challenges in the treatment of sleep disorders is poor compliance.1,20 Thus new treatments not only need to be effective but also be ones that people are motivated enough to use. Didgeridoo playing seems to meet these requirements. Participants were highly motivated during the trial and practised, on average, on almost six days a week, which was even more than the protocol asked for.Strengths and limitations of trial
Strengths of our trial include the long duration of the training so that effects could develop. Also, we blinded outcomes assessors when possible (sleep studies) and controlled for confounding by restricting the study sample to non-obese patients with little alcohol and drug consumption. A limitation is that those in the control group were simply put on a waiting list because a sham intervention for didgeridoo playing would be difficult. A control intervention such as playing a recorder would have been an option, but we would not be able to exclude effects on the upper airways and compliance might be poor. Another limitation is that the sample size was small. We conducted a proof of concept study and larger trials with more diverse study populations are needed to provide more precise estimates of the treatment effect of upper airway training.
In conclusion, didgeridoo playing improved daytime sleepiness in patients with moderate snoring and obstructive sleep apnoea and reduced sleep disturbance in their partners. Larger trials are needed to confirm our preliminary findings, but our results may give hope to the many people with moderate obstructive sleep apnoea syndrome and snoring, as well as to their partners.
What is already known on this topic
Snoring and obstructive sleep apnoea syndrome are highly prevalent sleep disorders associated with substantial morbidity and mortality and rising costs
Continuous positive airways pressure therapy can reduce daytime sleepiness, but compliance with this treatment is often poor
Training or electrostimulation of the muscles of the upper airway might reduce collapsibility of the upper airways during sleep
What this study adds
Regular playing of a didgeridoo reduces daytime sleepiness and snoring in people with moderate obstructive sleep apnoea syndrome and also improves the sleep quality of partners
Severity of disease, expressed by the apnoea-hypopnoea index, is also substantially reduced after four months of didgeridoo playing
Contributors: MAP, AS, and OB designed and organised the study. AS assigned the intervention. CLC, OB, MH, and AZ collected the data. MAP supervised data collection, analysed data, and wrote the first draft. AS, CLC, AZ, MH, and OB critically reviewed the manuscript, and MAP and OB prepared the final version. OB is guarantor.
Funding: Zurich Lung Association, Zuercher Hoehenklinik Wald.
Competing interests: AS is a professional didgeridoo instructor and teaches t'ai chi and qi gong.
Ethical approval: Ethics committee of the University Hospital of Zurich.
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